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Polacrillin Potassium

We inter duce Extra super disintegrant which has 10times higher swelling capacity over all other disintegrates below find complete write up along with % required of the same COA also enclosed for ready reference.
Polacrillin Potassium is derived from acrylate base polymer as per USP/NF. It is an effective super disintegrant as well as dissolution improver in solid dosage forms like tablets, Capsules , Pellets etc.

Polacrillin Potassium is available in white free flowing powder hence it is more suitable in direct compression system.
Polacrillin Potassium is a very high purity polymer finding use in Pharmaceutical formulation as a superb TABLET DISINTEGRANT for oral dosage formulations.
Required quantity is form 0.4% to 2% of avg. Weight of tablet on lubrication stage.
Disintegrant Agent : Polacrillin Potassium has a very high swelling tendency on hydration either in contact with water or G.I. Fluids causing fast disintegration without the formation of lumps and thus acts as an effective TABLET DISINTEGRANT.

For direct compression system, prepare drug granules with P.V.P. Or HPMC and avoiding use of starch or gelling binder.In these granules ,mix polacrillin potassium first and then mix lubricants. Prepare the tablet and put it in water or G.I. Fluid. Polacrillin Potassium absorbs water and break the tablet. A Ranitidine Hydrochloride tablet direct compression system was carried out to evalute the disintegration effect of Polacrillin Potassium in Comparison with cross P.V.P. And Cross Carmellose Sodium Using 1% the results are shown in figure
Ingredients Percentage
Ranitidne HCL 68
Microcrystalline Cellulose 28
Disintegrant 01
Talcum 02
Magnesium Stearate 01

Tablet Characteristic
Ranitidine HCL compression Disintegration Time
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Polacrillin Potassium is high molecular weight polymer, so doesn't get absorbed by body tissues & is safe for human cosumption. It has no physiological action at recommended dosage & it is non-toxic.
Store in tightly closed container. Keep away from moisture. If moisture is absorbed dry at 90*C to 100*C remove moisture content below 10%
5kg., 20kg., net in Leminated corrugated box with Polyethylene liner.